Deciphering Undruggable by ALLOSTERY

Inventing small molecule in the realm of drug discovery fostered by protein dynamics

Leveraging our cutting-edge technology based on protein dynamics, Nutshell is fostering a new era of drug discovery…

Our AlloStar allosteric drug discovery platform, composed of a powerful and well-integrated set of computational modules and experimental tools based on our proprietary AI algorithm and deep know-how derived from biochemistry and biophysics, possesses the unique capability to discover a host of drug entities including various types of protein activators, subtype/mutation selective small molecules, regulatory molecules of protein-protein interaction (PPI) and stabilizer of intrinsically disordered proteins (IDPs), thus opening up an unprecedented new horizon for small molecule innovation.

  • Sub-type selective allosteric inhibitor

  • Mutants selective allosteric inhibitor

  • Enzyme allosteric activator

  • Protein-protein interaction modulator

  • Disordered protein stabilize modulator

Current Pipeline

Project MoA Indications Discovery Lead to PCC IND enabling Phase I/II Phase III
p53 Y220C Allosteric activator Solid tumor
N009 (BIC) Allosteric inhibitor Solid tumor
N017 (BIC) Allosteric inhibitor Solid tumor
N019 (BIC) Allosteric inhibitor Solid tumor
N001 (FIC) Allosteric activator Metabolism
 
Potential FIC projects of various disease targets
 

Our Lab

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ADDRESS

Building E, No.1976 Middle Gaoke Rd. Pudong District, Shanghai, China

E-MAIL

contact@allonutshell.com;BD@allonutshell.com

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